English: Water plantain

Chinese: 泽泻

Parts used: Dried tuber

TCM category: Herbs that drain Dampness

TCM nature: Cold

TCM taste(s): Sweet

Organ affinity: Bladder Kidney

Scientific name: Alisma orientalis

Other names: Mad-dog weed

Use of Ze Xie (water plantain) in TCM

Please note that you should never self-prescribe TCM ingredients. A TCM ingredient is almost never eaten on its own but as part of a formula containing several ingredients that act together. Please consult a professional TCM practitioner, they will be best able to guide you.

Preparation: Remove impurities, soak slightly, cut in thick slices and dry.

Dosage: 6 - 10g.

Main actions according to TCM*: Causes urination and removes Damp-Heat

Primary conditions or symptoms for which Ze Xie may be prescribed by TCM doctors*: Edema Oliguria Urinary tract infection Hyperlipidemia

Contraindications*: Do not use during pregnancy or breast-feeding

Common TCM formulas in which Ze Xie is used*

Wu Ling San

Source date: 220 AD

Number of ingredients: 5 herbs

Formula key actions: Promotes urination,. Warms the Yang. Strengthens the Spleen. Promotes Qi transformation function. Drains Dampness. Clears edema.

Conditions targeted*: EdemaGlomerulonephritis and others

Ze Xie is a king ingredient in Wu Ling San. Like the name indicates, it means it has more power than other ingredients in the formula.

In Wu Ling San, Ze Xie leaches out Dampness and promotes urination. Its cold nature also enables it to eliminate the Stagnant Heat caused by water buildup.

Read more about Wu Ling San

Wei Ling Tang

Source date: 1481 AD

Number of ingredients: 9 herbs

Formula key actions: Promotes urination. Warms the Yang. Strengthens the Spleen. Drains Dampness. Promotes the movement of Qi. Harmonizes the Stomach.

Conditions targeted*: EdemaGastritis and others

Ze Xie is a king ingredient in Wei Ling Tang. Like the name indicates, it means it has more power than other ingredients in the formula.

In Wei Ling Tang, Ze Xie leaches out Dampness and promotes urination. Its cold nature helps to eliminate the Stagnant Heat caused by water buildup.

Read more about Wei Ling Tang

Shu Zao Yin Zi

Source date: 1253 AD

Number of ingredients: 11 herbs

Formula key actions: Purges and drives out Water. Clears Wind. Releases from the Exterior .

Conditions targeted*: Nephritis with EdemaIncreased intracranial pressure and others

Ze Xie is a deputy ingredient in Shu Zao Yin Zi. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Shu Zao Yin Zi, Ze Xie is a diuretic herb that promotes urination and dispels Dampness through the Bladder.

Read more about Shu Zao Yin Zi

Dang Gui Shao Yao San

Source date: 220 AD

Number of ingredients: 7 herbs

Formula key actions: Nourishes the Liver Blood. Spreads the Liver Qi. Strengthens the Spleen. Resolves Dampness.

Conditions targeted*: Perimenstrual migrainesEndometritis and others

Ze Xie is a deputy ingredient in Dang Gui Shao Yao San. This means it helps the king ingredient(s) treat the main pattern or it serves to treat a coexisting pattern.

In Dang Gui Shao Yao San, Ze Xie enters into the Kidneys and Bladder to promote water metabolism and leach out Dampness.

It assist the King ingredient in removing Stagnation by dredging the
vessels and collaterals.

Read more about Dang Gui Shao Yao San

Liu Wei Di Huang Wan

Source date: 1119 AD

Number of ingredients: 6 herbs

Formula key actions: Enriches the yin and nourishes the Kidneys.

Conditions targeted*: Chronic nephritisProstate diseases and others

Ze Xie is an assistant ingredient in Liu Wei Di Huang Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Liu Wei Di Huang Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Prepared rehmannia) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Liu Wei Di Huang Wan

Ba Wei Di Huang Wan

Source date: 220 AD

Number of ingredients: 8 herbs

Formula key actions: Tonifies Yang. Warms the Kidneys and lower extremities.

Conditions targeted*: Diabetes mellitusDiabetes insipidus and others

Ze Xie is an assistant ingredient in Ba Wei Di Huang Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ba Wei Di Huang Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Prepared rehmannia) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Ba Wei Di Huang Wan

Qi Ju Di Huang Wan

Source date: 1350 AD

Number of ingredients: 8 herbs

Formula key actions: Nourishes Kidney and Liver Yin. Improves vision.

Conditions targeted*: Diabetes mellitusDiabetes insipidus and others

Ze Xie is an assistant ingredient in Qi Ju Di Huang Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Qi Ju Di Huang Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Prepared rehmannia) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Qi Ju Di Huang Wan

Long Dan Xie Gan Tang

Source date: 1682 AD

Number of ingredients: 10 herbs

Formula key actions: Clears Heat and Fire from the Liver and Gallbladder. Clears and drains Damp-Heat from the Lower Burner.

Conditions targeted*: FurunclesPurulent otitis and others

Ze Xie is an assistant ingredient in Long Dan Xie Gan Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

Read more about Long Dan Xie Gan Tang

Zhi Bo Di Huang Wan

Source date: 1584 AD

Number of ingredients: 8 herbs

Formula key actions: Tonifies Yin. Drains Fire.

Ze Xie is an assistant ingredient in Zhi Bo Di Huang Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Zhi Bo Di Huang Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Shu Di Huang) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Zhi Bo Di Huang Wan

Ba Xian Chang Shou Wan

Source date: 1615 AD

Number of ingredients: 8 herbs

Formula key actions: Treats Yin Deficiency of the Lungs and Kidneys.

Ze Xie is an assistant ingredient in Ba Xian Chang Shou Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ba Xian Chang Shou Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Prepared rehmannia) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Ba Xian Chang Shou Wan

Zhi Shi Dao Zhi Wan

Source date: 1247 AD

Number of ingredients: 8 herbs

Formula key actions: Reduces and guides out stagnation and accumulation. Drains heat. Dispels dampness.

Ze Xie is an assistant ingredient in Zhi Shi Dao Zhi Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Zhi Shi Dao Zhi Wan, Ze Xie promotes water metabolism to facilitate the draining of Damp-Heat via the urine.

Read more about Zhi Shi Dao Zhi Wan

Ji Chuan Jian

Source date: 1624 AD

Number of ingredients: 6 herbs

Formula key actions: Warms the Kidneys . Nourishes the Blood . Strengthens the Essence . Moistens the Intestines. Unblocks bowels .

Conditions targeted*: ConstipationConstipation in the elderly and others

Ze Xie is an assistant ingredient in Ji Chuan Jian. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ji Chuan Jian, Ze Xie has a descending nature that drains turbidity from the Kidneys.

Together with Achyranthes root, it facilitates movement and guides the actions of the other herbs downward.

It also prevents the moistening property of the key herb from causing Stagnation.

Read more about Ji Chuan Jian

Ge Hua Jie Cheng San

Source date: 13th century

Number of ingredients: 13 herbs

Formula key actions: Separates and reduces alcohol-dampness. Warms the Middle. Strengthens the Spleen .

Conditions targeted*: HangoversAlcoholism and others

Ze Xie is an assistant ingredient in Ge Hua Jie Cheng San. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ge Hua Jie Cheng San, Ze Xie dispels Damp-Heat by promoting urination.

Read more about Ge Hua Jie Cheng San

Gui Ling Gan Lu Yin

Source date: 1172 AD

Number of ingredients: 9 herbs

Formula key actions: Expels Summerheat. Clears Heat. Transforms Qi. Removes Dampness .

Conditions targeted*: Acute gastroenteritisCholera and others

Ze Xie is an assistant ingredient in Gui Ling Gan Lu Yin. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Gui Ling Gan Lu Yin, Ze Xie promote urination and expel Dampness. Together, the four Dampness resolving assist herbs restore the ascending and descending functions of the Qi mechanism, transform the Bladder Qi , and alleviate sudden turmoil disorder.

Read more about Gui Ling Gan Lu Yin

Sheng Yang Yi Wei Tang

Source date: 1247 AD

Number of ingredients: 16 herbs

Formula key actions: Strengthens the Spleen. Augments the Qi. Raises the Yang. Releases Dampness.

Conditions targeted*: Atrophic gastritisChronic pelvic inflammatory disease and others

Ze Xie is an assistant ingredient in Sheng Yang Yi Wei Tang. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Sheng Yang Yi Wei Tang, Ze Xie drains Dampness and Heat from the Lower Burner. This facilitates the ascent of clear Yang, so as to treat dizziness and tinnitus caused by the accumulation of Damp-Heat in the Lower Burner. 

Read more about Sheng Yang Yi Wei Tang

Ji Sheng Shen Qi Wan

Source date: 1695 AD

Number of ingredients: 10 herbs

Formula key actions: Tonifies and warms Kidney Yang.

Conditions targeted*: EdemaHeavy back and others

Ze Xie is an assistant ingredient in Ji Sheng Shen Qi Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ji Sheng Shen Qi Wan, Ze Xie clears and drains the overabundance of Kidney fire. It is used here to prevent the rich, cloying properties of the chief herb Prepared rehmannia from congesting the mechanisms of the Kidneys, which will induce even more fire from Deficiency

Read more about Ji Sheng Shen Qi Wan

Ming Mu Di Huang Wan

Source date: 1642 AD

Number of ingredients: 12 herbs

Formula key actions: Nourishes the Liver. Enriches the Kidneys. Improves the vision.

Ze Xie is an assistant ingredient in Ming Mu Di Huang Wan. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Ming Mu Di Huang Wan, Ze Xie clears and drains the overabundance of Kidney Fire. It is used here to prevent the rich, cloying properties of the key herb (Prepared rehmannia) from congesting the mechanisms of the Kidneys, which would induce even more Heat from Deficiency.

Read more about Ming Mu Di Huang Wan

Xin Yi San

Source date: 1253 AD

Number of ingredients: 9 herbs

Formula key actions: Disperses Wind-Cold. Unblocks the nasal passages.

Conditions targeted*: Nasal congestionAllergic rhinitis and others

Ze Xie is an assistant ingredient in Xin Yi San. This means that it either serves to reinforces the effect of other ingredients or it moderates their toxicity.

In Xin Yi San, Ze Xie removes Damp-Heat by causes urination. 

Read more about Xin Yi San

Gui Shao Di Huang Tang

Source date: 1706 AD

Number of ingredients: 8 herbs

Formula key actions: Nourishes Blood. Nourishes Yin.

In Gui Shao Di Huang Tang, Ze Xie nourishes Liver and Kidney Yin

Read more about Gui Shao Di Huang Tang

Shen Qi Wan

Source date: 220 AD

Number of ingredients: 8 herbs

Formula key actions: Tonifies and warms Kidney Yang.

Conditions targeted*: Diabetes mellitusHyperaldosteronism and others

In Shen Qi Wan, Ze Xie clears and drains the overabundance of Kidney fire. It is used here to prevent the rich, cloying properties of the chief herb Prepared rehmannia from congesting the mechanisms of the Kidneys, which will induce
even more fire from Deficiency

Read more about Shen Qi Wan

Key TCM concepts behind Ze Xie's properties

In Traditional Chinese Medicine (TCM), Ze Xie belongs to the 'Herbs that drain Dampness' category. These herbs are typically diuretics, meaning that they promotes the increased production of urine in order to remove Dampness that has accumulated in the body. According to TCM Dampness accumulates first in the lower limbs, causing edema and impaired movement. From there, if unchecked, it can move upward and impair digestion and eventually the respiratory system.

Furthermore Ze Xie is Cold in nature. This means that Ze Xie typically helps people who have too much 'Heat' in their body. Balance between Yin and Yang is a key health concept in TCM. Those who have too much Heat in their body are said to either have a Yang Excess (because Yang is Hot in nature) or a Yin deficiency (Yin is Cold in Nature). Depending on your condition Ze Xie can help restore a harmonious balance between Yin and Yang.

Ze Xie also tastes Sweet. The so-called 'Five Phases' theory in Chinese Medicine states that the taste of TCM ingredients is a key determinant of their action in the body. Sweet ingredients like Ze Xie tends to slow down acute reactions and detoxify the body. They also have a tonic effect because they replenish Qi and Blood.

The tastes of ingredients in TCM also determine what Organs and Meridians they target. As such Ze Xie is thought to target the Bladder and the Kidney. In TCM the impure water collected by the Kidneys that cannot be used by the body is sent to the Bladder for storage and excretion as urine. The Kidneys do not only regulate the urinary system but also play a key role in the reproductive system and the growth and aging process of the body.

Research on Ze Xie

A new triterpenoid named alisol O was isolated from the rhizomes of Alisma orientalis and together with six known compounds and exhibited inhibitory activity in vitro on hepatitis B virus (HBV).1

Alisma orientalis methanolic extract showed hepatoprotective effects on nonalcoholic fatty liver disease and may be a potential clinical application for treatment of this chronic liver disease.2

Sources:

1. ZY Jiang, XM Zhang, FX Zhang, N Liu, F Zhao et al. (2006). A New Triterpene and Anti-Hepatitis B Virus Active Compounds from Alisma orientalis. Planta Med, 72(10): 951-954. DOI: 10.1055/s-2006-947178

2. Hong, X. , Tang, H. , Wu, L. and Li, L. (2006), Protective effects of the Alisma orientalis extract on the experimental nonalcoholic fatty liver disease. Journal of Pharmacy and Pharmacology, 58: 1391-1398. doi:10.1211/jpp.57.10.0013